Yes. The immunotherapy practice guidelines note that immunotherapy can be considered in patients with autoimmune or immunodeficiency conditions, and we have used SLIT safely in patients with these conditions in the past. Furthermore, some patients with autoimmune conditions have noted an improvement in their autoimmune condition (psoriasis, thyroid disease, rheumatoid arthritis, etc) after starting their SLIT drops without any other changes being made to their autoimmune condition treatment regimen. This phenomenon has not been formally studied to our knowledge, but we do know that the tolerogenic mechanisms promoted by SLIT do function on both an allergen-specific tolerance-promoting level as well as a more broad immune-calming level, the latter of which could certainly help improve autoimmune conditions as well.